Ligand-independent and EGF receptor-supported transactivation: Lessons from β2-adrenergic receptor signalling

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella et al. · New England Journal of Medicine · 2004 · 11.5K citations

Medicine, Oncology, Pharmacology +16

<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

J. Guillermo Paez, Pasi A. Jänne, Jeffrey C. Lee et al. · Science · 2004 · 9.4K citations

Medicine, Molecular Genetics, Oncology +17

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

Norbert Prenzel, Esther Zwick, Henrik Daub et al. · Nature · 1999 · 1.5K citations

Life Sciences, Biochemistry, Molecular Biology +15

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

Henrik Daub, Christian Wallasch, Axel Ullrich · Nature · 1996 · 1.5K citations

Life Sciences, Cell Biology, Molecular Biology +14

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

Yehia Daaka, Louis M. Luttrell, Robert J. Lefkowitz · Nature · 1997 · 1.3K citations

Life Sciences, Biochemistry, Pharmacology +16