Journal of Antimicrobial Chemotherapy · 1995 · 24 citations · 0 references
Life SciencesMicrobiologyPharmacologyAntimicrobial ResistanceMedical MicrobiologyMycologyAntifungal AgentsAntifungal PharmacologyAntifungal ResistanceAntifungal TherapyAntimicrobial Susceptibility TestingFungal DiagnosticsAntifungal Drug ResistanceAntifungal Susceptibility TestingCandida TherapyCandidiasis Drug ResistanceFungal Drug ResistanceMinimum Inhibitory Concentration DeterminationMinimum Inhibitory Concentration TestingNew Antifungal Agents
The in-vitro activity of sertaconazole (7-chloro-3-[1-(2,4-dichlorophenyl- 1-yl)ethoxy-methyl] benzo[b] thiophene) was compared with that of econazole and bifonazole against 150 strains of yeasts which includes six Candida species. Minimum inhibitory concentrations (MICs) were determined by a microdilution technique in Sabouraud's liquid medium, (pH 5.6). Sertaconazole (arithmetic mean MIC 0.77 mg/L) was more active than econazole (MIC 1.75 mg/L) and bifonazole (MIC 9.05 mg/L). MIC values for sertaconazole were generally and specifically lower for each tested species, Candida parapsilosis being the most susceptible (MIC 0.31 mg/L), in contrast to Candida tropicalis, which had the highest MIC (1.67 mg/L).