Healing pattern of small caliber Dacron grafts in the baboon: An animal model for the study of vascular prostheses

Abstract

Although dogs have been used widely to study the healing of large caliber synthetic grafts, hypercoagulability probably makes the dog a poor model for studies of small caliber vascular prostheses. The baboon's coagulation system is similar to man's, but large caliber baboon grafts were reported to endothelialize rapidly. In this study the healing pattern of 4 mm internal diameter Dacron carotid interposition grafts in baboons was determined using specimens harvested at time points between 2 weeks and 18 months post-implantation and examined with light and scanning electron microscopy. The luminal surface of baboon grafts in the acute healing phase (less than 1 month) was comparable to that reported in the literature for dogs. Baboon grafts did not completely endothelialize until 10-12 weeks post-implantation. For work with small caliber vascular prostheses, the dog appears to have no advantage over the baboon as an animal model on the basis of graft healing.