Journal of the Chemical Society Chemical Communications · 1980 · 22 citations · 0 references
Life SciencesBiochemistryChemistryHormone BiochemistrySpectroscopyStructural BiologyHormone StructurePeptide ChemistryProtein ConformationProtein StructureTertiary StructureX-ray CrystallographyHormone Primary StructureHormone Secondary StructureHormone Tertiary StructureMolecular Conformation AnalysisMolecular Conformation PredictionMolecular Structure DeterminationPeptide Secondary StructurePeptide Structure Analysis
An X-ray crystal study of thyrotropin-releasing hormone tartrate has revealed that its molecular structure, in contrast with predictions based on energy calculations and n.m.r. spectroscopic studies, contains an extended peptide bond stabilized by a hydrogen bond between the π-NH unit of histidine and the carbonyl oxygen of the proline amide.