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Molecular conformation of thyrotropin-releasing hormone from the X-ray structural analysis of its tartrate
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1980
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X-ray CrystallographyMolecular BiologyX-ray Crystal StudyPeptide ScienceProline AmideProtein FoldingProtein X-ray CrystallographyStructure ElucidationProtein ChemistryMolecular ConformationBiochemistryConformational StudyX-ray Structural AnalysisSolution Nmr SpectroscopyExtended Peptide BondMolecular ModelingCrystallographyStructural BiologyNatural SciencesPeptide SynthesisMolecular BiophysicsMedicineThyrotropin-releasing Hormone
An X-ray crystal study of thyrotropin-releasing hormone tartrate has revealed that its molecular structure, in contrast with predictions based on energy calculations and n.m.r. spectroscopic studies, contains an extended peptide bond stabilized by a hydrogen bond between the π-NH unit of histidine and the carbonyl oxygen of the proline amide.