Annals of the New York Academy of Sciences · 2003 · 10 citations · 11 references
MedicinePharmacologyPharmacotherapyNeuropharmacologyPain MedicinePain ScienceAnalgesiaAnalgesic PharmacologyNeuropathic PainPain NeurosciencePain PhysiologyPharmacologic Pain TherapyAnalgesic Drug MechanismsNeuropathic Pain ModulationNeuropathic Pain ReductionNeuropathic Pain ReliefPain PharmacologyPeripheral Analgesic MechanismsPharmacological Pain ReliefSciatic Nerve Surgery
This study was designed to investigate the effect of the endogenous beta-carboline, harmane, on neuropathic pain produced by chronic constriction injury (CCI) of the sciatic nerve. Thermal allodynia evaluations were made preoperatively, postoperatively on the fifteenth day, and after harmane administration. Harmane (1, 2.5, 5, 10, or 20 mg/kg) was administered intraperitoneally for 5 days beginning from postoperative day 15. Treatment with harmane had a profound anti-allodynic effect in a dose-dependent manner. In conclusion, harmane might provide a new approach to treatment of neuropathic pain.
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β-carboline binding to imidazoline receptors
Stephen M. Husbands, Richard A. Glennon, Stephane Gorgerat et al. · Drug and Alcohol Dependence · 2001 · 124 citations
On the neuropharmacology of Harmane and other β-carbolines
Klaus J. Fehske, Harald O. Borbe, U. Wollert et al. · Pharmacology Biochemistry and Behavior · 1981 · 107 citations
Medicine, Neuroscience, Pharmacology +10