Doxepin Induced Torsade De Pointes

Abstract

A case of torsade de pointes with normal QT interval secondary to the administration of small amounts of doxepin is presented. Electrophysiological studies during rechallenge with doxepin demonstrated replication of the patient's spontaneous arrhythmia. Evaluation of syncope in patients taking doxepin should include careful evaluation for torsade de pointes.