Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Jun S. Liu, Jesse D. Farmer, Willam S. Lane et al. · Cell · 1991 · 4.1K citations

Life Sciences, Biochemistry, Molecular Biology +8

FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION

ThomasE. Starzl, John J. Fung, Raman Venkataramman et al. · The Lancet · 1989 · 1.1K citations

Medicine, Pharmacokinetics, Surgery +12

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

Claude B. Klee, Barbara E. Bierer, Steven J. Burakoff · Proceedings of the National Academy of Sciences · 1992 · 820 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

Ted M. Dawson, Joseph Steiner, Valina L. Dawson et al. · Proceedings of the National Academy of Sciences · 1993 · 539 citations

Life Sciences, Neuroscience, Pharmacology +17

The long-term course of cyclosporine-associated chronic nephropathy

Bryan D. Myers, Richard Sibley, Lynne Newton et al. · Kidney International · 1988 · 513 citations · Full text

Medicine, Nephrology, Renal Pathology +12