Differentiation of nonbeating embryonic stem cells into beating cardiomyocytes is dependent on downregulation of PKCβ and ζ in concert with upregulation of PKCε

Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets

Nadya Lumelsky, Olivier Blondel, Pascal Laeng et al. · Science · 2001 · 1.5K citations

Adult Stem Cell, Embryonic Stem, Cell Differentiation +20

Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents.

Victor A. Maltsev, A. M. Wobus, J. Rohwedel et al. · Circulation Research · 1994 · 479 citations

Cardiac Muscle, Cardiac Progenitor Cells, Cell Differentiation +25

Pluripotent mouse embryonic stem cells are able to differentiate into cardiomyocytes expressing chronotropic responses to adrenergic and cholinergic agents and Ca2+ channel blockers

Anna M. Wobus, Gerd Wallukat, Jürgen Hescheler · Differentiation · 1991 · 470 citations

Cardiac Muscle, Induced Pluripotent Stem Cell, Developmental Biology +12

Increased Protein Kinase C Activity and Expression of Ca ²⁺ -Sensitive Isoforms in the Failing Human Heart

Nancy Bowling, Richard A. Walsh, Guojie Song et al. · Circulation · 1999 · 453 citations

SM22α, a Marker of Adult Smooth Muscle, Is Expressed in Multiple Myogenic Lineages During Embryogenesis

Li Li, Joseph M. Miano, Peter Cserjesi et al. · Circulation Research · 1996 · 407 citations

Cardiac Muscle, Genetics, Adult Smooth Muscle +22