Asymmetric Synthesis of Hexahydropyrrolo‐isoquinolines by an Organocatalytic Three‐Component Reaction

Abstract

Merging three in one by a three-component organocatalytic asymmetric reaction of imines and α-bromoesters or ketones with α,β-unsaturated aldehydes provides optically active pyrrolo-isoquinolines—an important class of molecules in life science. The reaction proceeds with excellent enantioselectivity and a number of transformations of the products obtained demonstrated the potential of the new reaction.