Enhancement of Arsenic Trioxide (As₂O₃)- Mediated Apoptosis Using Berberine in Human Neuroblastoma SH-SY5Y Cells

Abstract

Combined treatment of As(2)O(3) with berberine induced activation of apoptotic signaling pathways in HNB SH-SY5Y cells. These results suggest that the possibility of the combined treatment of two chemotherapeutic agents with low concentration improving cytotoxic effect for cancer cells with minimal side effects.