Adipose-Derived Stromal Vascular Fraction Cells and Platelet-Rich Plasma

TLDR

Autologous fat grafts are used in breast surgery, facial rejuvenation, buttock augmentation, Romberg syndrome, and liposuction sequelae. The study aims to describe how to isolate stromal vascular fraction and platelet‑rich plasma and to apply them to facial scar treatment. The authors treated 20 scar patients—10 with SVF‑enhanced fat grafts via the Celution System and 10 with Coleman fat grafts plus 0.5 mL PRP—and compared outcomes to a control group of 10 patients receiving centrifuged fat. SVF‑enhanced grafts achieved 63% contour maintenance versus 39% in controls, while fat grafts with PRP achieved 69% maintenance, indicating autologous fat grafting is effective for facial scar correction.

Abstract

Background Actually, autologous fat grafts have many clinical applications in breast surgery, facial rejuvenation, buttock augmentation, and Romberg syndrome as well as a treatment of liposuction sequelae. Objective The aim of this article was to describe the preparation and isolation procedures for stromal vascular fraction (SVF), the preparation of platelet-rich plasma (PRP), and the clinical application in the treatment of the scar on the face. Methods Ten patients with burns sequelae (n = 6) and post–traumatic scars (n = 4) were treated with SVF-enhanced autologous fat grafts obtained by the Celution System. Another 10 patients with burns sequelae (n = 5) and post–traumatic scars (n = 5) were treated with fat grafting based on the Coleman technique mixed with 0.5 mL of PRP. To assess the effects of their treatment, the authors compared their results with those of a control group consisting of 10 patients treated with centrifuged fat. Results In the patients treated with SVF-enhanced autologous fat grafts, we observed a 63% maintenance of contour restoring after 1 year compared with only 39% of the control group (n = 10) treated with centrifuged fat graft (P < 0.0001). In the patients treated with fat grafting and PRP, we observed a 69% maintenance of contour restoring after 1 year compared with that of the control group (n = 10). Conclusions Autologous fat grafting is a good method for the correction of scars on the face instead of the traditional scar surgical excision.