Intramolecular Imino Diels−Alder Reaction: Progress toward the Synthesis of Uncialamycin

Abstract

We herein described an intramolecular imino Diels-Alder reaction promoted with BF(3).OEt(2)/DDQ affording substituted quinolines. Using this procedure, we prepared the chiral quinoline moiety of the uncialamycin, a new enediyne natural product.