Synthesis of 2-Substituted Drivatives of Diltiazem

Abstract

Titled compounds, 2a, b, c, d and e, were efficientlysynthesized from 3-acetoxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one (4) through alkylation at the C 2 -position followed by stereoselective reduction of the C 3 -carbonyl group