Immobilization of heptakis 6-O-tert-butyldimethylsilyl-2,3-di-O-methyl)-β-cyclodextrin for capillary gas chromatography and SFC and micro-liquid chromatography

Abstract

Heptakis(6-O-tert-butyldimethylsilyl-2,3-di-O-methyl)-β-cyclodextrin was monofunctionalized by the introduction of linker-groups into the 2-, 3-, and 6-positions of the glucose monomer. The selectively modified cyclodextrin was bonded to dimethylpolysiloxane and immobilized to fused silica capillaries. It was also linked to aminopropyl silica by the formation of an amide bond. The new chiral stationary phases were applied in open tubular gas chromatography and SFC and in micro-liquid chromatography. © 1996 John Wiley & Sons, Inc. J Micro Sep 8: 495–505, 1996