Clinical Endocrinology · 1977 · 68 citations · 17 references
MedicineEndocrinologyPharmacologyEndocrine PharmacotherapyHormone BiochemistryPharmacodynamicsThyroid Axis RegulationThyroid DisordersThyroid EndocrinologyThyroid Hormone BiochemistryThyroid Uptake StudiesPeripheral Drug MetabolismPeripheral Hormone MetabolismPeripheral Thyroid Hormone MetabolismSingle-dose AdministrationThyroid Hormone PhysiologyThyroid Hormone SecretionTriiodothyronine Measurement
The effect of propranolol on plasma triiodothyronine (T3), thyroxine (T4) and triiodothyronine uptake by Sephadex G-25 (RT3U%) was studied in fourteen thyrotoxic patients and eight normal volunteers. 40 mg of propranolol as a single oral dose caused significant reduction in total serum T3 which began 60 min after administration. No significant changes were observed in T4 and RT3U% values. Plasma T3 levels remained suppressed during a 5 day course of treatment with propranolol. These results suggest that propranolol has a direct effect on peripheral metabolism of T3 rather than on thyroid hormone secretion.
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CONTROLLED TRIAL OF PROPRANOLOL IN THYROTOXICOSIS
R.G. Shanks, Dermot Lowe, D. R. Hadden et al. · The Lancet · 1969 · 151 citations