Tandem C−C Bond-Forming Processes: Interception of the Pd-Catalyzed Decarboxylative Allylation of Allyl Diphenylglycinate Imines with Activated Olefins

Abstract

Interception of the Pd-catalyzed decarboxylative allylation of allyl diphenylglycinate imines with appropriately functionalized Michael acceptors, followed by Heck cyclization, allows for the efficient construction of relatively complex organoamine frameworks in one reaction vessel. The initial intercepted decarboxylative allylation is remarkably insensitive toward solvent and catalyst, typically proceeding under ambient conditions.