Efficient Synthesis of Octaalkyloxy-o-quaterphenyls via Base-Induced Biaryl Coupling

Abstract

Octamethoxy-o-quaterphenyl (8a) was prepared in three steps from 4-bromo-1,2-dimethoxybenzene (5a) employing two base-mediated biaryl couplings. Demethylation of 8a followed by alkylation with decyl bromide gave the tetradecyloxy-o-quaterphenyl (8c).