Intravenous Administration of Bone Marrow Mesenchymal Stromal Cells is Safe for the Lung in a Chronic Myocardial Infarction Model

Abstract

Although the majority of intravenous infused cells were harbored in the lung, they did not cause deterioration of lung function. However, they did not activate the release of inflammatory/anti-inflammatory proteins, or stimulate angiogenesis or myogenesis in the old infarcted myocardium. Thus, intravenous administration of MSCs for chronic MI needs further experimental study.