Dornase Alpha Compared to Hypertonic Saline for Lung Atelectasis in Critically Ill Patients

Abstract

There was no significant improvement in the chest X-ray atelectasis score in mechanically ventilated patients with new onset atelectasis who were nebulized with Dornase alpha twice a day. Hypertonic saline was no more effective than normal saline in this population. Larger randomized control trials are needed to confirm our results.