Journal of Antimicrobial Chemotherapy · 1993 · 45 citations · 0 references
Health ProfessionsInfectious DiseasesSurgeryDiabetologyInfectious Diseases Of The FootMedical MicrobiologyAntibiotic Therapy For Foot InfectionsDiabetic Foot DiseaseDiabetic Neuropathic FootFoot InfectionsInfection ManagementWound InfectionAntibiotic Penetration Into Foot TissueClindamycin TherapyDiabetic Foot Infection ManagementFoot Soft Tissue InfectionsInfection In Foot UlcersPharmacokinetics In Foot InfectionsTissue PenetrationTissue Penetration Efficiency
Serum and tissue samples were obtained during surgery from four diabetics with neuropathy who underwent debridement or amputation for foot infections while receiving clindamycin 600 or 900 mg iv. Clindamycin concentrations were assayed by radioimmunoassay. Clindamycin was detected in all serum and tissue samples (range: 0.04-2.8 mg/kg in tissues and 1.1-11.1 mg/L in serum). In nine of the eleven tissue samples the clindamycin concentration exceeded the MICs reported for many pathogens commonly involved in such infections. In only a single instance was the ratio of tissue to serum concentration < 0.13.