A gene–gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin

Abstract

We report counteracting effects of the c.808 (G>T) and g.-66T>C on the renal elimination of metformin. When adjusted for the genetic variation g.-66T>C, our results suggest that c.808 (G>T) could have a dominant genotype to phenotype correlation.