Different effects of fluvoxamine on rabeprazole pharmacokinetics in relation to CYP2C19 genotype status

Abstract

The present study indicates that there are significant drug interactions between rabeprazole and fluvoxamine in EMs of CYP2C19. It is predominantly involved in rabeprazole and rabeprazole thioether metabolism in EMs. Therefore, CYP2C19 is the key determinant of rabeprazole disposition in EMs.