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Sleep characteristics in infantile spasms
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1981
Year
Sleep DisordersParasomniasSleep MedicineSleepSleep CharacteristicsSleep DisorderNeurophysiologyPediatricsTotal Sleep TimeInfantile SpasmsSleep PhysiologyNeuroscienceNeurologySleep StagingInsomniaMedicineEpilepsySocial Sciences
Sleep staging was performed on 32 infantile spasm patients, 17 of whom received ACTH or prednisone therapy. Patients exhibited reduced total sleep time and REM proportion compared to age‑matched norms; hormone therapy did not increase total sleep time, yet responders showed a significant rise in REM that paralleled clinical and electroencephalographic improvement, whereas non‑responders did not.
Sleep staging was performed on 32 patients with infantile spasms. All patients demonstrated significantly less total sleep time and lower percentage of REM time than the expected normal values for age. Seventeen were treated with ACTH or prednisone. There was no increase in total sleep time in those who received hormone therapy, whether or not it was successful. However, the percentage of REM time increased significantly in patients who responded to therapy; this increase occurred concurrently with clinical and electroencephalographic improvement. There was no significant change in REM-sleep values in patients who did not respond.