Publication | Open Access
L-Proline-Catalyzed Asymmetric Aldol Condensation of N-Substituted Isatins with Acetone
54
Citations
6
References
2006
Year
Asymmetric CatalysisNovel MechanismEngineeringBiochemistryNatural SciencesOrganic ChemistryCatalysisStereoselective SynthesisChemistryEe ValueNatural Product SynthesisN-substituted IsatinsSynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringSeveral Isatin Derivatives
L-proline-catalyzed asymmetric aldol condensation of several isatin derivatives with acetone is reported.The desired products were obtained in highly yield with the ee among 30-79%.The substitutes of N can deeply effect the ee value of products, and a novel mechanism is also described.
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