Baculovirus is an efficient vector for the transduction of the eye: comparison of baculovirus‐ and adenovirus‐mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye

Abstract

The study suggests that baculoviruses are efficient vectors for ocular gene transfer, especially if deeper retinal layers need to be transduced. In addition, intravitreal VEGF-D gene transfer caused blood-retina barrier breakdown but not neovessel formation in the rabbit eye.