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Iodine as an Efficient Catalyst for One-Pot Multicomponent Synthesis of β-Acetamido Ketones
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2006
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Efficient CatalystChemical EngineeringCross-coupling ReactionAromatic AldehydesEngineeringCatalytic SynthesisOrganic ChemistryOne-pot Multicomponent SynthesisCatalysisChemistryβ-Acetamido KetonesEnolizable KetonesEnantioselective SynthesisBiomolecular Engineering
Iodine efficiently catalyzes the three-component coupling of aromatic aldehydes, enolizable ketones or keto esters, and acetonitrile in the presence of acetyl chloride to afford β-acetamido ketones in good yields at room temperature.