Trisomy 21, fetal hydrops, and anemia: Prenatal diagnosis of transient myeloproliferative disorder?

Abstract

Nonimmune fetal hydrops and trisomy 21 may be associated without cardiac or anatomical anomalies. Transient myeloproliferative disorder has been seen in neonates with trisomy 21 and may be a cause of hydrops in some aneuploid fetuses. Chromosomal analysis should not be excluded in the workup of nonimmune hydrops when anemia is found, and therapy may be withheld until karyotyping has been performed.