Proceedings of the National Academy of Sciences · 2014 · 159 citations · 15 references
EngineeringElectrical EngineeringMaterials ScienceBiosensorsNanotechnologySensorsBiosensor DesignElectrochemical DetectionElectrochemical SensorsNanomaterial-based BiosensorsNanosensorsNanowiresBiosensor Sensitivity EnhancementCapacitanceField-effect Transistor BiosensorsNanowire BiosensorsNanowire DevicesSensitivitySurface Area-to-volume RatioSurface-to-volume Ratio Effects
Electrostatic counter ion screening is a phenomenon that is detrimental to the sensitivity of charge detection in electrolytic environments, such as in field-effect transistor-based biosensors. Using simple analytical arguments, we show that electrostatic screening is weaker in the vicinity of concave curved surfaces, and stronger in the vicinity of convex surfaces. We use this insight to show, using numerical simulations, that the enhanced sensitivity observed in nanoscale biosensors is due to binding of biomolecules in concave corners where screening is reduced. We show that the traditional argument, that increased surface area-to-volume ratio for nanoscale sensors is responsible for their increased sensitivity, is incorrect.
15
An integrated semiconductor device enabling non-optical genome sequencing
Jonathan M. Rothberg, Wolfgang Hinz, Todd M. Rearick et al. · Nature · 2011 · 2.2K citations · Full text
Label-free immunodetection with CMOS-compatible semiconducting nanowires
Eric Stern, James F. Klemic, David A. Routenberg et al. · Nature · 2007 · 1.3K citations