Synthesis and spectroscopic studies of the pyrimidine-2(1<i>H</i>)thione derivatives

Abstract

1,3-Diaryl-2-propen-1-ones 1 reacted with thiourea in the presence of sodium ethoxide to give 4,6-diaryl-3,4-dihydropyrimidine-2(1H)thiones 5 which upon dehydrogenation with 3 mol of ethanolic sodium ethoxide yielded the corresponding 4,6-diarylpyrimidine-2(1H)thiones 9. The N-acetyl derivatives of the former thiones were prepared. Infrared, nuclear magnetic resonance, and ultraviolet spectral data of the above compounds were tabulated and discussed.