THIAZOLE DERIVATIVES OF SULFANILAMIDE

Abstract

Recently, Fosbinder and Walter¹have described the preparation of certain sulfanilamide derivatives of heterocyclic amines. Among these compounds were described sulfanilamide derivatives of the thiazole series, namely 2 - para-nitro - benzenesulfonamido - 4-methylthiazole, 2-N⁴-acetylsulfanilamido-4-methylthiazole, 2-N⁴-acetylsulfanilamidothiazole, 2-sulfanilamido-4-methylthiazole and 2-sulfanilamidothiazole. Similar compounds have been synthesized by Lott and Bergeim.²Two of these compounds, sulfathiazole (2(para-amino-benzene-sulfonamido) thiazole) and sulfamethylthiazole (2(para-amino-benzene-sulfonamido) 4-methylthiazole) have been distributed for experimental use and clinical investigation. The names have not yet been considered by the Council on Pharmacy and Chemistry. It has been reported³that the acute toxicity of sulfathiazole (when administered as the sodium salt by the parenteral route) is definitely less than that of the corresponding sodium salt of sulfapyridine when administered by the same route. The experience with this compound in our division confirms this observation, and we have noted that the sodium salt of the methyl and phenyl derivatives of