Effect of the Long-Term Treatment with Trandolapril on Endoglin Expression in Rats with Experimental Renal Fibrosis Induced by Renal Mass Reduction

Abstract

The present study demonstrates an increased TGF-beta1, endoglin, collagen type I and collagen type IV expression in rats with severe hypertension and renal damage. The effect of trandolapril to decrease renal fibrosis seems to be based in a reduced TGF-beta1 expression but not in an increased expression of endoglin.