An efficient regioselective hydrodifluoromethylation of unactivated alkenes with TMSCF₂CO₂Et at ambient temperature

Abstract

A mild, versatile and efficient method for the regioselective hydrodifluoromethylation of unactivated alkenes has been developed. This Ag-mediated Csp(3)-CF2 bond forming reaction provides easy access to a variety of vicinal α-difluoroacetate-containing alkanes.