Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through α<sub>v</sub>β<sub>3</sub>‐ or α<sub>5</sub>β<sub>1</sub>‐Integrins - Concepedia

Concepedia

Publication | Open Access

Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through α<sub>v</sub>β<sub>3</sub>‐ or α<sub>5</sub>β<sub>1</sub>‐Integrins

DOI Full Paper Access

63

Citations

27

References

2013

Year

Sabri Rahmouni, Aaron Lindner, Florian Rechenmacher, Stefanie Neubauer, Tariq R. Sobahi, Horst Kessler, Elisabetta Ada Cavalcanti‐Adam, Joachim P. Spatz

Advanced Materials

Ethylene GlycolNanotherapeuticsEngineeringNew ToolCell AdhesionBiomaterials DesignPolyelectrolyte GelBiofabricationHydrogel MicropillarsBiomedical EngineeringCell-substrate InteractionsHydrogelsGold NanopatternsMatrix BiologyBiophysicsBiomaterialsIntegrin Selective LigandsBiopolymer GelCell-matrix InteractionMedicineCell Traction ForcesBiointerfaceExtracellular Matrix

Abstract

Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5β1- and αvβ3-integrins. Cells adherent via α5β1-integrins have a tendency to exert higher maximum forces than cells adhering via αvβ3-integrins.

References

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