Role of the Genetic Polymorphisms in the 5′‐Flanking Region for Transcriptional Regulation of the Human <i>CYP2E1</i> Gene

Abstract

The region including the tandem repeat polymorphism was suggested to regulate transcription suppressively. Besides, it was speculated that the transcriptional activity of CYP2E1*1D was higher than that of CYP2E1*1C because transcriptional suppression of CYP2E1*1D was weaker than that of CYP2E1*1C. Also, it was confirmed that the region including RsaI polymorphism was associated with the promotion of transcription.