Biology of the Cell · 1988 · 40 citations · 14 references
MedicineDevelopmental BiologyMolecular GeneticsCarcinogenesisGene ExpressionOncogenesBone DevelopmentBone FormationBone TumorsOncogenic VirusesSkeletal DevelopmentViral OncogenesDna In Situ HybridizationFos OncogenesOncogenic RetrovirusesOncogenic Viral GenesOncogenic Virus BiologyTransgenic MiceViral Oncogene ExpressionViral Transformation
The c-fos proto-oncogene is the cellular homologue of v-fos identified as the bone transforming gene of the FBJ and the FBR murine osteosarcoma viruses. We show here, using a sensitive in situ hybridization method, that the c-fos proto-oncogene is expressed in the cartilage, bone and tooth forming tissues during mouse development. This result suggests that the tumors observed after infection by the FBJ viral complex and c-fos overexpression in transgenic mice occur in those tissues in which c-fos is expressed during development.
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Common DNA binding site for Fos protein complexesand transcription factor AP-1
Frank J. Rauscher, Lidia Sambucetti, Tom Curran et al. · Cell · 1988 · 614 citations
Deregulated c-fos expression interferes with normal bone development in transgenic mice
Ulrich Rüther, Christa Garber, D. Komitowski et al. · Nature · 1987 · 336 citations