ABNORMALITY OF ESTROGEN METABOLISM IN HUMAN SUBJECTS WITH MYOCARDIAL INFARCTION

Abstract

Estrogen metabolism has been investigated in male subjects with and without previous myocardial infarction. The urinary excretion of estriol, estrone, and estradiol-17β has been measured 1 day before and 4 days after intramuscular injection of estradiol-17β. The excretion of the individual estrogens resulting from the administration of estradiol was determined by subtracting preinjection values from the daily excretion following injection. The resultant values of estriol (T), estrone (O), and estradiol-l7β (D) were expressed as the following ratios:[Formula: see text]These urinary estrogen ratios were found to be significantly higher in subjects with previous myocardial infarction than in control subjects. The ratios in the infarction group were not influenced by bed rest nor by the duration of time following infarction which varied from 1 week to 2 years.