An Efficient Approach to Chiral Ferrocene‐Based Secondary Alcohols <i>via</i> Asymmetric Hydrogenation of Ferrocenyl Ketones

Abstract

Abstract P‐Phos‐ruthenium‐DPEN precatalysts have been found to be efficient for the asymmetric hydrogenation of various ferrocenyl ketones. The use of ( R )‐xylyl‐P‐PhosRuCl 2 ( R , R )‐DPEN generated chiral ferrocenylethanol in 99.3% e.e. with &gt;99% conversion in a 150‐g scale.