Population Pharmacokinetics of Extended-Release Injectable Naltrexone (XR-NTX) in Patients With Alcohol Dependence

Abstract

Although statistically significant covariate-parameter relationships were identified, they were not considered clinically meaningful, suggesting that dosing adjustments of XR-NTX based on weight, age, gender, health status, smoking status, creatinine CL, and hepatic function differences should not be necessary.