Concepedia

Cholesterol glucosylation by Helicobacter pylori delays internalization and arrests phagosome maturation in macrophages

Shin-Yi Du, Hung‐Jung Wang, Hsin‐Hung Cheng, Sheng-De Chen, Lily Wang, Wen‐Ching Wang

Journal of Microbiology Immunology and Infection · 2014 · 48 citations · 18 references

DOIFull text

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Abstract

Cholesterol glucosylation by H. pylori interferes with phagosome trafficking via a lipid-raft and PI3K-dependent manner, which retards engulfment of bacteria for prolonged intracellular survival of H. pylori.

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