Journal of the American Chemical Society · 2012 · 196 citations · 46 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryArene FunctionalizationAsymmetric Heterocycle SynthesisC - H Bond FunctionalizationEnantioselective SynthesisHeterocycle FunctionalizationNitrogen Heterocycles
Enantioselective copper-catalyzed cyclization of γ-alkenylsulfonamides and a δ-alkenylsulfonamide in the presence of a range of vinyl arenes results in variously functionalized 2-substituted chiral nitrogen heterocycles via a formal alkene C-H functionalization process. Application of this reaction to the concise synthesis of a 5-HT(7) receptor antagonist is demonstrated.
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