Fetal Alcohol Exposure Alters GAP‐43 Phosphorylation and Protein Kinase C Responses to Contextual Fear Conditioning in the Hippocampus of Adult Rat Offspring

Abstract

Considering the role of PKC activation and GAP-43 phosphorylation in synaptic plasticity, our results suggest that deficient translocation of PKC beta2 and PKC epsilon in the hippocampus may mediate the electrophysiological and behavioral deficits observed in fetal alcohol exposed animals.