Prognostic and therapeutic impact of the chromosome 20q13.2 <i>ZNF217</i> locus amplification in ovarian clear cell carcinoma

Abstract

These findings indicate that ZNF217 overexpression is critical to growth and survival of OCCCs with ZNF217 gene amplification. Furthermore, they suggest that ZNF217 siRNA-induced phenotypes depend on amplification status of OCCCs. Therefore, ZNF217-targeted therapy may benefit OCCC patients with ZNF217 amplification.