Quetiapine with lithium or divalproex for the treatment of bipolar mania: a randomized, double‐blind, placebo‐controlled study

Abstract

Quetiapine combined with either Li or DVP has superior efficacy compared with Li or DVP monotherapy for treating patients with bipolar mania. Combination therapy was well-tolerated and most adverse events were mild, withdrawal because of adverse events being only 5% compared with 6% on Li or DVP monotherapy.