Pharmacokinetic Profile and Efficacy of a Fentanyl Transdermal Delivery System for Acute Postoperative Pain after Intra‐abdominal Gynecologic Surgery for Cancer

Abstract

The transdermal therapeutic system for administration of fentanyl, combined with epidural administration of a nonopioid analgesic such as bupivacaine is effective in controlling postoperative pain after gynecologic surgery. Additionally, the safety/tolerability of this regimen was similar to placebo plus bupivacaine.