Effective Nonenzymatic Kinetic Resolution of Racemic<i>m</i>-Nitro-Substituted Inherently Chiral Aminocalix[4]arenes

Abstract

Effective nonenzymatic kinetic resolution of racemic m-nitro-substituted inherently chiral aminocalix[4]arenes with Boc-l-proline as the acylating reagent is described, which provides an efficient and convenient method for the enantioselective synthesis of meta-substituted aminocalix[4]arenes.