Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Proceedings of the National Academy of Sciences · 1987 · 2.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

Studies With RP 56976 (Taxotere): A Semisynthetic Analogue of Taxol

Israel Ringel, Susan Band Horwitz · JNCI Journal of the National Cancer Institute · 1991 · 674 citations

Medicine, Oncology, Pharmacology +15

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

Masaru Horio, Michael M. Gottesman, Ira Pastan · Proceedings of the National Academy of Sciences · 1988 · 480 citations · Full text

Medicine, Oncology, Pharmacology +17

Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators

Janice Hunter, Mark A. Jepson, T Tsuruo et al. · Journal of Biological Chemistry · 1993 · 367 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17