Anti-bacterial glycosyl triazoles – identification of an<i>N</i>-acetylglucosamine derivative with bacteriostatic activity against<i>Bacillus</i>

Abstract

cultured in the presence of sub-MIC amounts of the glycosyl triazole inhibitors exhibit an elongated phenotype characteristic of impaired cell division. This represents the first report of inhibitors of bacterial cell wall GlcNAcases that demonstrate inhibition of cell growth in whole cell assays.