A neural tissue interfacing chip for in-vitro applications with 32k recording / stimulation channels on an active area of 2.6 mm<sup>2</sup>

Abstract

A neural tissue interfacing chip for in-vitro applications is presented based on an extended 0.5 μm, 5 V, standard CMOS process. The chip provides 256 × 128 bidirectional recording / stimulation sites on a total active area of 2.28 mm × 1.14 mm, and a fully digital interface. Full frame recording rate is 2.4 kHz. Selection of a subset of sites is possible and translates into higher bandwidth per site accordingly. Electrical and biological results are presented which reveal proper functionality.