Acid-Catalyzed Synthesis of Bicyclo[3.<i>n</i>.1]alkenediones

Abstract

An acid-catalyzed Dieckmann-type reaction has been developed to access functionalized bicyclo[3.2.1]alkenediones. This methodology has been successfully extended to more substituted and larger ring homologues, providing a new and efficient route to the core of numerous attractive natural products and their analogues.