Ophthalmic Research · 2009 · 20 citations · 0 references
MedicineImmunologyPharmacologyInflammationOcular ImmunologySignal TransductionImmunopathology Of The EyeInflammatory SignalingOcular AllergyOcular InflammationOcular PharmacodynamicsRetinal ImmunologyAnti-inflammatory Ocular Drug EffectsAnti-inflammatory Ocular TherapyMediators Of Ocular InflammationOcular SensitizationUveitis PathogenesisUveitis Pharmacotherapy
Modulation of signal transduction at the surface of inflammatory cells appears to influence acute inflammation. Adenosine, a well-known chemical messenger, inhibits the production of superoxide by stimulated neutrophils. In experimental allergic uveitis induced by sensitization with retinal 's' antigen, treatment with adenosine produced a marked reduction in the expected inflammation.